The Effects of CBD on Depersonalization/Derealization(DPDR)

This article will focus on the research side of the effects of CBD on Depersonalization/Derealization. The medical community is looking to utilize the benefits of CBD for treating several ailments, such as PTSD, Anxiety-related disorders(Depersonalization, General Anxiety Disorder, etc.), Depression, and tons of other ailments. The cannabinoids which are active components of cannabis are responsible for its amazing effects on people. In the cannabis plant, there are multiple cannabinoids that are psychoactive, such as THC, and some are nonpsychoactive, such as CBD. The psychoactive compounds can induce the “high” effect in a person whereas the nonpsychoactive compounds do not induce any “high” feeling. Before we start getting anymore deeper, It is important to have a look at what Depersonalization-derealization disorder really is.

Depersonalization-derealization disorder

Depersonalization/derealization disorder is an altered condition of self-awareness and identity that results in a feeling of separation or dissociation from oneself, one’s environment, or both. It is normal to feel this way briefly and it is often due to the side effects of medication, recreational drugs, or some other physical or psychological health conditions. Depersonalization/derealization disorder (DPD) is typically diagnosed only if these feelings of separation frequently occur, cause anguish, and/or meddle with your quality of life. (Psychology Today, 2018)

So, DPD occurs when a person constantly feels like they are observing themselves from outside their body or if they sense that things around them are not real. Feelings of DPD can be extremely disturbing and may feel like a person is living in a fantasy. (Mayo Clinic, 2018). The disorder tends to be attached to the person’s anxiety, as in if the person experiences anxiety, they are likely to experience Depersonalization. When this happens, Depersonalization tends to make the person way more anxious, thus creating a snowball effect of anxiety.


  • Depersonalization is a feeling of experiencing your own behavior, thoughts, and feelings from an illusory perspective.
  • Individuals with this issue will, by and large, begin giving signs in early youth; symptoms rarely occur for the first time in adults beyond 40 years of age, unless a recreational drug induced the disorder, such as LSD, Marijuana, DMT, or other psychedelics.
  • One may feel emotionally numb, or like they are not controlling their own actions and words. People experiencing such condition may also feel detached from ordinary sensations, such as touch, thirst, hunger, and libido.
  • Derealization is a feeling of separation from activities going on in the world outside of yourself.
  • The world may even appear distorted and unrecognizable as if things are the wrong size or color, time is speeding up or slowing down, or sounds are louder/softer than expected.
  • The feeling of separation-related with depersonalization/derealization disorder is like watching events and activities unfold in a movie or on a computer screen, instead of really taking part in what is happening around.
  • Episodes can go on for a considerable length of time and may even repeat for quite a long time: day, months, or even years.
  • Usually, a person experiencing DPD is aware of both the inner thoughts and what is going on around them, so they are conscious of the fact that they feel separated from themselves and their surroundings.
  • These episodes may cause extraordinary misery and make it troublesome to function normally at work, in school, or in a social setting.
  • It’s regular for individuals with depersonalization/derealization disorder to think that they do not generally exist, or that their symptoms are the result of irreversible brain damage (Psychology Today, 2018).


The exact cause of depersonalization-derealization disorder aren’t well understood, but here’s what we know:

  • Depersonalization/Derealization Disorder seems to occur a little more frequently in women than men.
  • A history of severe stress, neglect, physical or psychological mistreatment can prompt depersonalization/derealization disorder.
  • Studies have demonstrated that poor sleep quality is related to more extreme symptoms of separation. Even certain drugs or psychedelics have been shown to trigger the onset.
  • A few people might be more susceptible to depersonalization and derealization than others, possibly due to environmental and genetic factors.
  • Increased levels of stress and anxiety may trigger episodes.
  • Childhood trauma or other experiences or occasions that cause severe emotional anxiety, stress or trauma may lead to Depersonalization

Risk Factors

Some things that may increase the risk of depersonalization-derealization disorder include:

  • Depression or anxiety, particularly extreme or prolonged episodes
  • Certain personality traits that make a person want to stay away or deny difficult circumstances, or personality traits that make it difficult to adapt to troublesome circumstances. These traits tend to bring out Social Anxiety, which can play a role in bringing out Depersonalization
  • Extreme trauma, during childhood or as an adult. For example, encountering or seeing a traumatic event
  • Extreme stress, for example, work-related, financial, or relationship issues
  • Using recreational drugs, that can initiate episodes of depersonalization or derealization, such as LSD, Marijuana, or other psychedelic drugs


Since the depersonalization/derealization disorder frequently happens with (and can be stimulated by) other psychological issues, for example, anxiety and depression, treatment can be difficult for some.

  • Psychotherapy: Various psychotherapies can be useful to the individuals who experience the ill effects of the disorder, including cognitive and behavioral techniques, grounding exercises, and psychodynamic therapy.
  • Medication: anti-anxiety and antidepressant medicines are frequently used to treat depersonalization/derealization disorder, however, most of these have negative side effects or actually promote anxiety in some people.

Investigations indicate a need for more alternative treatments which are based on the case studies and experiences of clinicians who have some expertise in dissociative disorders. Research shows that as CBD is helpful in treating stress and anxiety issues properly, it can also be effective in depersonalization/derealization disorder.

CBD and Depersonalization/Derealization

CBD’s (Cannabidiol) most important property is that it is nonpsychoactive, meaning it doesn’t get you high or make you perceive things any different. It is mostly used in the form of oil so it’s easy to use. It eliminates the harmful effects of THC such as intoxication, drowsiness or getting high. The endocannabinoid system holds the chief part with CBD. It joins to the cannabinoid receptors in different parts of the body particularly in the Central Nervous System through the antipsychotic effect (Tokes, 2016).

The nonpsychoactive nature of CBD is extraordinary when used with THC because it cancels out the “high” properties of THC while also keeping all of the medicinal applications; you get all of the medicinal without any of the high. It is one of the best reasons that medical experts are recommending it as an analgesic and anti-anxiety drug to their patients.

The immense therapeutic potential advantages of CBD help in the treatment of many medical ailments. CBD diminishes the level of anxiety, possess anti-inflammatory characteristics, aids seizures, treats pain, provides neuroprotection and promotes better sleep (ANXIETY HACK, 2018). CBD supports physiological benefits generally by binding with CB1 and CB2 receptors on cells all throughout the body and brain.


CBD research denotes that it is very helpful in epilepsy, chronic pain, anxiety, depression, diabetes, psychotic disorders, inflammation, and cancer. Depersonalization/Derealization is induced by anxiety and is a common symptom of the raised levels of stress, anxiety. More detail over this is as follows:

A report was introduced in regards to anxiolytic(anti-anxiety) properties of the CBD in generalized social anxiety disorder. It concluded that CBD lowers the level of anxiety in social anxiety disorders in the paralimbic and limbic territories of the brain (Martin-Santos, Wichert-Ana, Derenusson, & Ferrari, 2011).

PTSD leads to severe stress, anxiety, and depression. Just like depersonalization/derealization, which needs to be eliminated to ease the treatment. CBD may possess anti-depressive properties that help people with PTSD who are experiencing depression (Halpern, Passie, Brandt, Emrich, & Karst, 2012). At the point when a patient is stressed after they are diagnosed with a chronic disease, CBD is exceptionally viable for them as they can emphasize and focus on their treatment without any stress and anxiety. (Shalev, Roitman, Cooper-Kazaz, & Mechoulam, 2014).

It additionally reasoned that CBD can diminish short-term brain injuries and furthermore extracerebral advantages (Alvarez, Lafuente, Rey-Santano, Mielgo, & Gastiasoro, 2008).

A transitional study report of thirty years suggested that CBD successfully helps psychotic disorders such as schizophrenia due to the antipsychotic properties that CBD contains (Zuardi, Crippa, Hallak, Bhattacharyya, & Atakan, 2012).

Does CBD induce Depersonalization/Derealization

It has been noted that excessive use of cannabis can induce depersonalization/derealization, this is because cannabis contains both psychoactive and nonpsychoactive compounds. And if people are consuming excessive psychoactive compounds, then they may develop depersonalization/derealization. Since CBD has nonpsychoactive properties, it does not promote depersonalization/derealization at all. CBD has been shown to lower anxiety, stress, and depression in many situations.

Does Full-Spectrum CBD induce DPD since it contains THC?

Our Full-Spectrum CBD Oil does not induce DPD even though it has THC in it. This is because we have less than 0.3% THC in all of our products, which is too small of an amount for any impact to happen on your brain. It’s also important to note that CBD has been shown to cancel out the effects of THC, so there is no way you can feel high off our products. All of the 100+ cannabinoids(including THC) help heal your body in a synchronized way, called the ‘Entourage Effect.’ This effect promotes more anti-anxiety properties, thus lowering individual’s Depersonalization. We recommend taking 3 drops of 300mg oil under your tongue right when you start to feel an episode coming on, and within 2-3 minutes the CBD will kick in and start reducing your anxiety, thus reducing your Depersonalization!


Depersonalization/derealization disorder is an altered condition of self-awareness and identity that results in a feeling of separation or, dissociation, from oneself, one’s environment, or both. It is normal to feel this way briefly, and is often due to side effects of medication, recreational drugs, or some other mental conditions. It is induced by anxiety in most cases. Research shows that CBD is helpful in treating stress and anxiety. It has shown to also be effective in treating depersonalization/derealization disorder because of its anti-anxiety properties. It is a misconception that CBD promotes depersonalization/derealization, as CBD is a nonpsychoactive compound. It not only lowers anxiety, stress, and depression but it also eradicates the toxic effects of psychoactive compounds in cannabis. CBD possess anxiolytic(anti-anxiety) properties and acts as an efficient anti-anxiety and anti-depressant for the people with depersonalization/derealization disorder.

Want to read some more CBD research articles? Click below to go back to the blog homepage.

Did you learn what you were looking for? Check out our shop to see if you'd like anything!

Quick Help

Welcome to our new store!!

We are so excited to bring you a new website experience! So excited, in fact, that we are having a site-wide discount through the first 3 months!